Edward B. Lee, M.D., Ph.D., graduated Phi Beta Kappa and with honors from Stanford (1997), and obtained his M.D. and Ph.D. degrees from the University of Pennsylvania (2005) where he studied amyloid pathology in various experimental models under the mentorship of Virginia M.-Y. Lee, PhD. After clinical training in Anatomic Pathology and Neuropathology at the Hospital of the University of Pennsylvania, Edward was appointed Assistant Professor in 2011 and promoted to Associate Professor with tenure in 2021 in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania. Edward is currently principle investigator of the Translational Neuropathology Research Laboratory (TNRL). TNRL supports studies on the molecular neuropathology of Alzheimer’s disease, frontotemporal degeneration and amyotrophic lateral sclerosis, recently discovering a novel form of dementia called vacuolar tauopathy. He is also an attending physician at the Hospital of the University of Pennsylvania, Associate Director of the Penn Alzheimer’s Disease Research Center, Brain Bank leader of the CONNECT-TBI Consortium, and co-leader of the NIH supported Penn Neurodegenerative Disease Brain Bank. Edward has published greater than 130 peer-reviewed manuscripts and reviews in high impact journals such as Science, Nature Medicine, Neuron, PNAS, Brain, Acta Neuropathologica, and others.